Mefenamic acid fast disintegrating tablets were formulated by using sublimation method to reduce the bitter taste and first pass hepatic metabolism with a view to enhance patient compliance. Three different superdisintegrants viz., crospovidone, croscarmellose sodium and sodium starch glycolate were used in different ratios (6% and 12%) along with camphor, beta cyclodextrin, microcrystalline cellulose and saccharin sodium. Camphor is used as sublimating agent and saccharin sodium is used as taste masking agent. The formulated tablets were evaluated for post formulation parameters. FTIR studies indicate that the drug and excipients are compatible and also the stability studies indicate that there were no significant changes in the formulation.
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